|Benign Trigeminal Sensory
A syndrome of isolated (though occasionally,
bilateral) facial numbness, gradual in onset,
which may involve a single division of the
Trigeminal Nerve or all 3 divisions.
Some cases are idiopathic but many underlying diseases,
especially connective tissue ones, can cause Trigeminal
Sensory Neuropathy (TSN).
|Last Updated 27th April 2016
When an apparent cause is not detected, the disease is defined as Idiopathic
Trigeminal Sensory Neuropathy (ITSN), which is usually transient.
ITSN is always considered an exclusion diagnosis, so that various systemic,
intra-cranial (within the skull) and extra-cranial (outside the skull) disorders must
first be eliminated.
Classically, involvement of the Trigeminal Nerve is related to demyelinating
diseases (such as Multiple Sclerosis), the presence of tumours, vascular
diseases, trauma, local injections, terminal kidney disease, infections, drugs and
connective tissue diseases.
Of this group of disorders, Multiple Sclerosis and connective tissue diseases, as
well as ITSN, are of particular importance.
Trigeminal neuropathy most commonly manifests as numbness in the face or
mucous membranes, sometimes in association with masticatory weakness,
paresthesiæ, and / or pain.
Although many patients may be eventually labeled as having idiopathic TNO, the
diverse and potentially life-threatening etiologies that may underlie TNO demand a
complete evaluation. A patient labelled as having idiopathic TNO deserves a high
index of suspicion for missed diagnoses, which may only reveal themselves with
Treatment should be aimed at targeting the underlying patho-physiology, if
identified and treatment of complications, which may be uncomfortable, disabling,
or potentially life-threatening to the patient.
|Treatment Approach to Trigeminal Neuropathy