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Hæmophilia & Von Willebrand's Disease & Oral Surgery
Patients with Hæmophilia (Factors VIII & IX Deficiencies) & Von Willebrand's Disease

Hæmophilia is a group of hereditary genetic disorders that impair the body's ability to control coagulation (blood
clotting).

Hæmophilia A (Clotting Factor VIII deficiency) is the most common form of the disorder (1 in 5,000 – 10,000 male
births).

Hæmophilia B (Clotting Factor IX deficiency) is rarer than Hæmophilia A, occuring in around 1 in about 20,000 –
34,000 male births.

Hæmophilia lowers blood plasma clotting factor levels of the coagulation factors needed for normal coagulation.  
When a blood vessel is injured, a
clot does form but the missing coagulation factors prevent fibrin formation, which is
necessary to maintain the blood
clot.

A
hæmophiliac does not bleed more intensely than a person without it but can bleed for a much longer time.  In
severe cases, even a minor injury can result in bleeding that can last days - weeks or there is incomplete healing.  In
areas such as the brain or inside joints, this can be fatal or permanently debilitating.
Useful Articles:

St James Hospital, Dublin.  Haemophilia & Dental Care

Austral Dental J 2001.  A Protocol for the Dental Management of Von Willebrand's Disease, Hæmophilia A &
Hæmophilia B.

UK Haemophilia Centre Doctors’ Organization

Haemophilia 2005.  Dental Procedures in Adult Patients with Hereditary Bleeding Disorders.  10 Years Experience in
3 Italian Hemophilia Centers

J Dent Res 2005.  Hereditary Blood Coagulation Disorders -  Management and Dental Treatment

World Federation of Hæmophilia 2005.  Guidelines for the Management of Hæmophilia

Treatment of Hæmophilia 2006.  Guidelines for Dental Treatment of Patients with Inherited Bleeding Disorders

Canadian Hæmophilia Society 2007.  All About von Willebrand Disease

Treatment of Hæmophilia 2008.  Dental Management of Patients with Inhibitors to Factor VIII or Factor IX

Treatment of Hæmophilia 2008.  Oral Care for People with Hæmophilia or a Hereditary Bleeding Tendency

N Engl J Med 2009.  Clinical Problem Solving.  A Bloody Mystery (Acquired von Willebrand’s Disease)

Barts & the London NHS Trust 2010.  Dental Management of Haemophilia Patients

N Engl J Med 2012.  Factor XIII in the Treatment of Hemophilia A

Dent Update 2013. Special Care Dentistry Part 1.  Dental Management of Patients with Inherited Bleeding Disorders
Last Updated 26th February 2014