Necrotising Sialometaplasia
What is Necrotising Sialadenometaplasia / Sialometaplasia?

Necrotising Sialadenometaplasia / Sialometaplasia is an uncommon, usually self-limiting, variably
ulcerated, benign (i.e. non-cancerous), inflammatory process, predominantly affecting salivary tissue (any
site in the body that contains elements of the salivary gland, from the
para-nasal sinuses to the lung).

The importance of the lesion is that it
mimics the appearance of malignant disease, both clinically and
microscopically.  Failure to recognize
necrotising sialometaplasia may result in unnecessary radical
surgery because of an erroneous pre-operative diagnosis of
squamous cell carcinoma or
muco-epidermoid carcinoma.
Photos of Necrotising Sialometaplasia in the Palate
Roof of Mouth)
What is the Cause of Necrotising Sialadenometaplasia / Sialometaplasia?

Although the ætio-pathogenesis of necrotising sialometaplasia remains unknown there is general consensus that a
reduced blood flow (
ischæmic) event in the salivary gland precedes the development of the lesion.

This condition may occur after local trauma, including surgical manipulation or injection of local anæsthesia into the
involved area.

For patients who have had surgery, the lesion becomes clinically evident in about 3 weeks or longer.  
may also appear spontaneously, often without the history of prior surgical or traumatic event.  No
particular oral condition or habit has been associated with this condition to date.

The disease has been reported in patients with vasculopathies which predispose to
ischæmia (such as Sickle Cell
, where infarction may be a feature in crisis, Buerger’s disease and Raynaud’s phenomenon).

Addition of a
vaso-constrictor (such as adrenaline) to local anæsthetic solutions, local radiotherapy, cocaine use,
pressure from local
space-occupying lesions and surgery have also been implicated.  The lesion may be more
florid in pregnancy.

There is also an association with preceding
upper respiratory tract infection within the previous few weeks,
particularly acute on chronic
sinusitis and allergy.  It is possible that the ischæmic event in these cases is due to
immune complex disease, similar to the ætiology of erythema multiforme or benign trigeminal sensory

It has been suggested that
necrotising sialometaplasia of the palate may represent an ulcerative or necrotising
stage of
smoker’s keratosis although this now seems unlikely.

Other predisposing factors include:

  • intubation
  • bronchoscopy
  • local anæsthetic injection
  • vascular damage due to trauma
  • smoking and alcohol
  • hot food
  • fellatio and
  • recurrent vomiting

There may be an association with tumours, specifically:

  • Warthin’s tumour
  • Abrisokov’s tumour
  • carcinoma of the lip
  • rapidly growing mesenchymal malignancy and
  • salivary gland tumours.

What are the signs and symptoms of Sialadenometaplasia / Sialometaplasia?

Men are affected approximately twice as often as women.  Mean age of occurrence in men is about 50 years and
36 years in women (the youngest reported case is 15 years).  There appears to be an increased incidence in
males.  There was a 5:1 preponderance of Caucasians over Afro-Caribbeans.

Necrotising sialometaplasia is extremely rare - there are barely 200 cases reported in the world literature.

The vast majority (80%) of cases affect the
minor salivary glands of the palate, while other sites include gum
behind the lower wisdom teeth (
retro-molar pad), lip, tongue and cheek.

The condition has also been reported in
major salivary glands.  Rarely, the condition has also been reported at
extra-salivary sites, which include:

  • nose
  • naso-pharynx
  • trachea
  • larynx and
  • lung.

At extra-salivary sites, the lesion may be described as
adenometaplasia.  A similar lesion occurs in the skin,
syringometaplasia and similar histo-pathological appearances have been described in the breast following

The lesion has a sudden onset, and is clinically characterized by a
nodular swelling that leads to a painful, crater-
like ulcer, 1 – 5 cm in diameter, with an irregular, ragged border.  
The lesion mimics a carcinoma and is usually
located on the
posterior palate (most commonly at the junction of the hard and soft palates).

Symptoms are generally disproportionately slight, compared with the size of the lesion.  Most patients indicate
surprisingly mild complaints of tenderness or dull pain.  Pain may also be a feature at the onset and may be intense
and referral of the pain to the ear, eye and pharynx are variable features which have been reported.  However,
development of the lesion may be painless and there are even reports of anæsthesia of the
Greater Palatine Nerve
as the presenting feature.  This is thought to be caused by involvement of the
vasa nervorum in the vasculitic
ætiological process.

The lesions may occur bilaterally and metachronously.

When ulceration occurs, it usually remains superficial, but a single case of full-thickness
necrosis of the palate has
been reported.

Injection of anti-inflammatory
steroids into the lesions appears to offer no benefit on recovery time of the lesion or
associated anæsthesia.

Differential diagnosis of an ulcer presenting with these features could include:

  • direct traumatic ulceration
  • major aphthous ulceration
  • syphilis
  • tuberculosis
  • deep mycosis
  • agranulocytosis
  • neutropænia
  • nicorandil-induced oral ulceration
  • malignancy, in particular squamous cell carcinoma, low-grade muco-epidermoid carcinoma and oncocytic

How is it treated?

The lesion usually heals spontaneously within 4 – 8 weeks.

The usual management of this condition is simple observation until the healing phase is complete.

Necrotising sialometaplasia may occur de novo, after trauma or a surgical procedure or in association with other
lesions, either benign or malignant.  Because of the latter, whenever the diagnosis of
necrotising sialometaplasia is
made, close follow up is indicated until healing is complete.  Recognition of the histological picture and the varied
clinical settings in which
necrotising sialometaplasia can be found, is essential to avoid histo-pathological mis-
interpretation and inappropriate treatment for this benign reactive condition.

The prognosis is excellent, once the correct diagnosis is made.

There are no known preventative strategies.

If the lesions are large, incisional biopsy should be done to establish a definitive diagnosis.

Healing takes place over several weeks by secondary intention.  Reassuring the patient and lavaging the wound
with irrigation or rinsing may be helpful.  Once the lesion has healed, recurrence and functional impairment are not
Last Updated 5th January 2020
Useful Website:

European Association of Oral Medicine

Useful Articles:

J American Dental Association 1996. Necrotizing sialometaplasia: literature review and case reports

Ear, Nose & Throat Journal 2003.  Necrotizing Sialometaplasia

J Irish Dent Ass 2005.  Necrotizing Sialometaplasia - An Important Diagnosis. Review of the Literature & Spectrum
of Clinical Presentation

Oral Oncology 2006. Case Report. Necrotizing sialometaplasia of the palate

J Canadian Dental Association 2007.  Sialometaplasia of the Soft Palate in a 2-Year-Old Girl
Cases Journal 2009.  Case report.  Bilateral localization of necrotizing sialometaplasia.  A case report

JOMS 2013.  Necrotizing Sialometaplasia in a Patient with an Eating Disorder - Palatal Ulcer Accompanied by
Dental Erosion Due to Binge-Purging

SRM J Res Dent Sci 2013.  Necrotising Sialometaplasia - A Deceptive Ulcer of the Palate.  A Case Report

J Oral Maxillofac Path 2014.  Necrotizing Sialometaplasia - A Diagnostic Dilemma

BDJ 2015.  Letters to the Editor.  Case Report.  Palatal mucosal necrosis after administration of a palatal infiltration

BDJ 2016.  Mouth Cancer.  Acute Necrotising Sialometaplasia

BMJ Case Rep 2016.  Necrotising Sialometaplasia at Multiple Sites - A Therapeutic Challenge to Oral Physicians

Ann Emerg Med 2017.  Images in Emergency Medicine.  Necrotizing Sialometaplasia

Med Buccale Chir Buccale 2017.  Persistent Ulceration of the Oral Floor - A Case of Necrotizing Sialometaplasia of
the Sublingual Gland?

Dental Update 2018.  Necrotizing Sialometaplasia − A Diagnostic Conundrum

Innovations Tissue Eng Regen Med 2018.  Cancerous Caricature, Fester, Transformation - Necrotizing